Pot roast gyros are the ultimate fusion of hearty, slow-cooked comfort food and vibrant Mediterranean flavors. Imagine tender, juicy pot roast wrapped in warm pita bread, topped with creamy tzatziki and fresh veggies. This dish transforms a classic Sunday dinner into a weeknight favorite that’s both satisfying and easy to make. In this blog, we’ll guide you through a foolproof pot roast gyro recipe, share expert tips, and highlight why this dish is a must-try for food lovers.
Here’s why you’ll love this dish:
- Versatile: Use leftover pot roast or start from scratch.
- Flavorful: Combines the umami of beef with zesty Mediterranean ingredients.
- Crowd-Pleaser: Ideal for family dinners or casual gatherings.
Ingredients
- 2–3 lbs chuck roast
- 1 tbsp olive oil
- 1 tsp salt
- 1 tsp black pepper
- 1 tsp garlic powder
- 1 tsp dried oregano
- 1 cup beef broth
- 4–6 pita breads
- 1 cup tzatziki sauce (store-bought or homemade, see this recipe)
- 1 cup sliced tomatoes
- 1 cup sliced red onions
- 1 cup shredded lettuce
- Optional: crumbled feta cheese
How To Make Recipe

- Prepare the Pot Roast:
- Season the chuck roast with salt, pepper, garlic powder, and oregano.
- Heat olive oil in a skillet and sear the roast on all sides until browned.
- Transfer to a slow cooker, add beef broth, and cook on low for 8 hours or until fork-tender.
- Shred the beef using two forks.
- Assemble the Gyros:
- Warm the pita bread in the oven or on a skillet.
- Spread a generous layer of tzatziki sauce on each pita.
- Add a portion of shredded pot roast, followed by tomatoes, onions, lettuce, and feta (if using).
- Fold the pita around the filling or wrap in foil for easy eating.
- Serve and Enjoy:
- Pair with a side of Greek salad or fries for a complete meal.
- Serve immediately for the freshest flavors.

Tips for the Best Pot Roast Gyros
To ensure your pot roast gyros are a hit, keep these expert tips in mind:
- Use Quality Pita: Opt for soft, fluffy pita bread from a local bakery or trusted brand like Oroweat.
- Make Your Own Tzatziki: Homemade tzatziki adds a fresh, authentic touch. Blend yogurt, cucumber, garlic, and dill for a quick sauce.
- Don’t Skip the Sear: Searing the roast locks in flavor, making your gyros irresistibly savory.
- Customize Toppings: Add pickled peppers or olives for an extra Mediterranean kick.